Ten years after a plague turned most of the world's population into vampires, a critical blood shortage is causing panic and gruesome mutations within the undead community. Edward (Ethan Hawke), a vampire hematologist, is trying to develop a blood substitute when he meets Lionel (Willem Dafoe) and Audrey (Claudia Karvan), two fugitive humans who claim to have a possible cure for vampirism. Edward casts his lot in with Lionel and Audrey in the hope of perfecting the cure before it's too late.

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